As an important part of drug development, chemically synthesised drugs are still the subject of new drug development by the world’s major pharmaceutical companies today. The production of chemical drugs cannot be separated from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals or synthetic organic compounds, active monomers derived from natural drugs, or antibiotics obtained by fermentation methods.
Natural products are the largest and best source of drugs. Not only are all drugs used in traditional medicine worldwide of natural origin, but even more than 30% of the chemical drugs used in modern medicine are compounds of natural origin, and many more are produced by structural modification and modification of natural products as lead compounds. The diversity of natural product structures and biological activities not only provides direct access to new drugs or drug lead compounds, but also provides inspiration for chemical synthesis and structural modifications. The discovery of structurally novel lead compounds with antiviral and antitumor activities from medicinal plants is one of the important directions for the development of antiviral and antitumor drugs.
Anti-microbial drug resistance is rife today and has the potential to affect people of any age in any country. Many of the medical breakthroughs made in the last century may be lost due to the spread of antimicrobial resistance, and previously curable infectious diseases may become untreatable and spread worldwide. Antimicrobial resistance is a global problem, and in the last few years the use and misuse of antimicrobial drugs has increased the number and variety of resistant microorganisms. The consequence is that many infectious diseases may once again become uncontrollable. With increased global trade and travel, drug-resistant microorganisms may rapidly spread to every corner of the world.
The application of combinatorial chemistry to the acquisition of new compound molecules is a development of bionanotechnology. It assembles a number of basic small molecules into different combinations, thus creating a library of chemical molecules with a large number of compounds, which is then combined with high-throughput screening to find a number of active lead compounds.
Organic compounds as a source of chemosynthetic drugs
The majority of drugs are organic compounds and synthetic drugs are now prepared by synthetic methods of organic chemistry. At present, chemically synthesised drugs are still the most effective, most commonly used, most abundant and most important therapeutic agents. The theme of new drug research by the world’s major pharmaceutical companies today remains chemically synthesised drugs
In the 21st century, the invention of a number of advanced computer instruments, the continuous improvement of separation and analytical methods, and especially the further micronisation of analytical methods will lead to a higher quality of chemically synthesised drugs and a further acceleration of their development. As a result, the chemical manufacturer malaysia has been emerging since then.